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["附件："]
["2022年度通过综合验收的济南市临床医学科技创新计划拟拨付经费项目名单"]
["序号","项目编号","项目名称","承担单位","主管部门"]
[1,201907001,"miRNA-140-5P在小儿先天性巨结肠发病机制中的研究","山东省立医院","山东省立医院"]
[2,201907002,"肥胖患儿生长激素-胰岛素样生长因子轴激素水平改变与肠道菌群失调相关性临床研究","山东大学第二医院","山东大学第二医院"]
[3,201907004,"基于济南地区医疗大数据平台指导儿童社区获得性肺炎中西医结合防治方案研究","山东中医药大学","山东中医药大学"]
[4,201907007,"基于质谱检测、基因测序技术的遗传代谢性肝病研究","济南市儿童医院","济南市卫健委"]
[5,201907011,"纳米载体用于子痫前期靶向治疗的实验研究","山东省立医院","山东省立医院"]
[6,201907012,"杀伤细胞免疫球蛋白样受体作为复发性流早产诊断标志物的应用研究","山东省立医院","山东省立医院"]
[7,201907013,"m6A修饰对妊娠期糖尿病发病的作用及机制研究","济南市妇幼保健院","济南市卫健委"]
[8,201907014,"MenSCs/PRP自组装多肽水凝胶支架的构建及其在薄型内膜和宫腔黏连修复再生中的作用机制与应用研究","济南市中心医院","济南市卫健委"]
[9,201907017,"超声造影在乳腺癌术后子宫内膜风险评估中的应用研究","济南市人民医院","济南市卫健委"]
[10,201907018,"mRNA核质转运复合体调节细胞DNA损伤修复机制及肺癌诊治的临床应用研究","济南市中心医院","济南市卫健委"]
[11,201907021,"自噬在原发性免疫性血小板减少症的临床应用研究","山东省立医院","山东省立医院"]
[12,201907023,"接受造血干细胞移植患者生活质量评价体系的建立及基于GVHD相关分子机制干预的研究","山东省立医院","山东省立医院"]
[13,201907025,"体位、呼吸气相对双肺后部小GGO影像学征象的影响","济南市中西医结合医院","济南市卫健委"]
[14,201907026,"青蒿琥酯纳米脂质体治疗急性髓系白血病的临床疗效研究","山东省立医院","山东省立医院"]
[15,201907029,"吡非尼酮通过RAC1/NOX4途径抑制缺氧性肺动脉成纤维细胞的实验研究","济南市中心医院","济南市卫健委"]
[16,201907032,"转化生长因子-β1及其下游因子在百日咳致病中的作用","济南市儿童医院","济南市卫健委"]
[17,201907033,"NLRX1信号通路在CYP2J2基因抗病毒性心肌炎中的作用和机制研究","山东省立医院","山东省立医院"]
[18,201907035,"转录抑制因子HMBOX1在酒精性肝病发展过程中的保护作用及美他多辛的干预机","山东大学第二医院","山东大学第二医院"]
[19,201907037,"TSH通过G蛋白亚单位调控巨噬细胞炎症及其机制","山东省立医院","山东省立医院"]
[20,201907038,"内源性大麻素系统在肠易激综合征发病机制中的研究","山东省立医院","山东省立医院"]
[21,201907044,"高血压病中西医预警体系构建与应用研究","山东中医药大学","山东中医药大学"]
[22,201907045,"人口老龄化背景下老年综合征管理模型构建及应用","山东省立医院","山东省立医院"]
[23,201907048,"KPNA2调控雌激素介导的细胞周期进入S期信号通路在胶质瘤发生过程中的作用研究","山东省立医院","山东省立医院"]
[24,201907050,"预防性应用替罗非班对颅内大动脉粥样硬化性狭窄支架置入术的安全性及有效性研究","山东省千佛山医院","山东省千佛山医院"]
[25,201907060,"标准TSH抑制治疗程序下术后甲状腺乳头状癌患者心血管风险的纵向队列研究","山东省立医院","山东省立医院"]
[26,201907062,"前列腺癌一体化诊疗平台下精准医疗成果应用推广","山东省立医院","山东省立医院"]
[27,201907067,"直肠型便秘精准手术治疗关键技术的研究","山东省千佛山医院","山东省千佛山医院"]
[28,201907068,"腹壁无切口腹腔镜结直肠癌根治术的临床应用研究","山东省立医院","山东省立医院"]
[29,201907073,"胆管癌基因突变图谱与临床特征关联研究","山东省立医院","山东省立医院"]
[30,201907076,"雪旺氏细胞和神经干细胞联合移植治疗脊髓损伤的实验研究","济南市第三人民医院","济南市卫健委"]
[31,201907078,"膝关节置换术后以社区医院为主导的延续护理模式构建及效果评价","山东省千佛山医院","山东省千佛山医院"]
[32,201907079,"解毒洗药熏洗治疗脂质硬皮症的疗效评价及机制研究","山东中医药大学","山东中医药大学"]
[33,201907086,"机器人辅助体外通道螺钉置入固定骨盆环损伤的方法设计和生物力学研究","济南市第三人民医院","济南市卫健委"]
[34,201907087,"生物膜构建密闭环境下Allen III型指端组织再生的临床及愈合机制研究","济南市第三人民医院","济南市卫健委"]
[35,201907091,"电子喉镜窄带光（NBI）技术在咽喉反流(LPR)疾病诊断中的应用","山东省千佛山医院","山东省千佛山医院"]
[36,201907094,"利用高通量测序技术筛选顺铂耳毒性相关的关键LncRNA分子的靶向应用研究","山东省立医院","山东省立医院"]
[37,201907095,"血管因子VG5Q在糖尿病视网膜病变中的作用及其机制研究","山东省立医院","山东省立医院"]
[38,201907100,"羊膜镜的研发及临床应用研究","济南市第二人民医院","济南市卫健委"]
[39,201907102,"飞秒激光进行角膜移植的临床研究","济南市第二人民医院","济南市卫健委"]
[40,201907103,"补肾活血胶囊治疗早期激素性股骨头坏死的临床疗效评价与影像学、力学分析","山东中医药大学","山东中医药大学"]
[41,201907104,"基于温病热毒理论及TLRs/NF-κB信号通路探讨加味升降散抗流感的实验及临床研究","济南市中医医院","济南市卫健委"]
[42,201907105,"“四明穴”为主小儿推拿防治儿童近视优化方案临床研究","山东中医药大学","山东中医药大学"]
[43,201907106,"子宫腺肌病中医证候分布规律和中成药联用方案临床优势疗效评价的研究","山东中医药大学","山东中医药大学"]
[44,201907107,"基于表观遗传修饰间的交互作用探讨糖肾康对糖尿病肾病足细胞的保护作用","山东中医药大学","山东中医药大学"]
[45,201907110,"肿瘤相关巨噬细胞ILT4调控非小细胞肺癌免疫逃逸及发生发展的相关研究","济南市中心医院","济南市卫健委"]
[46,201907111,"Myd88-IFNrR1二聚体通过Sphk2重塑肠道肿瘤免疫微环境抗结肠癌的机制研究","济南市中心医院","济南市卫健委"]
[47,201907112,"p53对非小细胞肺癌IGF-1R单抗的增效作用及机制研究","山东省立医院","山东省立医院"]
[48,201907113,"代谢与增殖显像指导非小细胞肺癌个体化放疗靶区剂量雕刻的临床应用研究","山东省肿瘤医院","山东省医科院"]
[49,201907115,"基于字典学习影像组学技术联合改进IVIM影像对ESCC新辅助放化抵抗定量预测指标的研究","山东省肿瘤医院","山东省医科院"]
[50,201907116,"双重抑制Hsp90/CKS1的PADI3抗癌多肽在结肠癌治疗中的应用研究","山东省公共卫生临床中心（济南市传染病医院）","山东省卫健委"]
[51,201907117,"内酰胺酶LACTB通过调控EMT增强肺腺癌多西他赛化疗敏感性的机制研究","济南市中心医院","济南市卫健委"]
[52,201907119,"智能释放Hn3抗体修饰载KLF14纳米金靶向肝癌细胞载体研发","山东省千佛山医院","山东省千佛山医院"]
[53,201907120,"利用条件重编程细胞培养技术建立胃癌个体化化疗药物评价体系的研究","山东省肿瘤医院","山东省医科院"]
[54,201907121,"肿瘤相关巨噬细胞通过iNOS信号通路在非小细胞肺癌发生和转移中的机制研究","济南市中心医院","济南市卫健委"]
[55,201907124,"二甲双胍联合TACE治疗中晚期肝癌的临床研究","山东省肿瘤医院","山东省医科院"]
[56,202019127,"地佐辛对肺癌患者DC免疫功能的影响及机制研究","山东大学第二医院","山东大学第二医院"]

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